B: Cells were enriched with the indicated fatty acid (200 mol/L) in GM for 24 h. After the 72-h fatty acid enrichment, interleukin 1 (IL-1 10 ng/mL) was added directly to the wells containing the fatty acid-supplemented medium, and the cells were collected and prepared for analysis after 2 and 4 h of IL-1 exposure. A: Cells were enriched with the indicated fatty acid (200 mol/L) in growth medium (GM) for 72 h. Thus, the purpose of this review is to advance the science of CLA and to identify areas of research in which these nutrients affect bone metabolism and skeletal health.Ĭyclooxygenase 2 (COX-2) protein level (normalized by-actin) in MC3T3-E1 osteoblast-like cells enriched with different fatty acids (200 mol/L). Here, we briefly review the current biological effects of CLA and attempt to integrate their potential effect on the physiology and health of the skeletal system. Recognizing where related actions of CLA converge in specific disease conditions and physiologic states is how research efforts should be directed to minimize the pursuit of superfluous theories. As such, the principal and consistently reported benefits of CLA have been in improving cancer outcomes, reducing body fat in growing animals, and modulating cell functions. The disappointing results in humans should be taken as an opportunity to critically evaluate all findings of CLA use and to consolidate the common actions of this nutrient so that future investigations focus on specific isomers and the most reasonable mechanisms.
The benefits to human subjects given supplements of CLA were at best modest. However, the demonstration that these isomers of octadecadienoic acid protect against cancers in rodents stimulated curiosity that directed significant resources to characterize the biological functions of these fatty acids in cell and animal models. The general truth is that conjugated linoleic acids (CLAs) are nutrients.
#Ockham cary nc free
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